|Prices:||from $0.34 per pill
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|Forms:||Antabuse (Disulfiram) 250 mg, 500 mg tablets
|Type:||Disulfiram brand, Antabuse generic
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Disulfiram (trade names include Antabuse, Antabus, Antaethyl, Anticol, Antietanol, Esperal, Etabus, Etiltox, Sarcoton, Tetradin, Teturam) is an alcohol-abuse deterrent medication from drugs used in alcohol dependence pharmacological group. This medicine is used for the treatment of alcoholism, chronic alcoholism, alcohol use disorder. It helps patients with alcohol abuse problems not to drink alcohol. Disulfiram is in research studies for the therapy of HIV, COVID-19, liver metastasis, metastatic melanoma, glioblastoma, non-small cell lung cancer, prostate cancer, parasitic infections such as amebiasis, diarrhea, liver abscess caused by Entamoeba histolytica and other deadly parasites. Antabuse works by interfering with the way the body metabolises alcohol (when taken with alcohol, this medication produces unpleasant effects).
Pharmacological and medical categories:
Indications and usage:
Antabuse (Disulfiram) is a medication used to treat alcohol dependence. It works by blocking an enzyme that breaks down alcohol in the body. This means that when people who are taking disulfiram drink alcohol, they develop a number of unpleasant symptoms known as the "aldehyde reaction".
Dosage and administration:
Oral dosage for the maintenance treatment of alcohol dependence: initially, 500 mg PO once daily every morning for 1 to 2 weeks, then reduce to 250 mg PO once daily. The dose may be taken in the evening if drowsiness occurs. Recommended maintenance dosage range: 125 mg to 500 mg PO once daily. Max: 500 mg/day PO. Required duration of treatment ranges from months to years, and is dependent on the patient's ability to abstain from ingesting alcohol. Pharmacotherapy should be used as a part of a comprehensive management program that includes psychosocial support and treatment.
Dosage forms and strengt:
High doses of disulfiram (up to 6 g daily) are relatively non-toxic in man. Antabuse is toxic to animals only in large doses. The LD50 of a single dose administration in the dog is 3.5 g/kg and in the rat 8.6 g/kg. Death occurs by respiratory arrest, preceded by ascending paralysis, and pathological lesions are seen in the liver, spleen, kidney and CNS, with congestion in the adrenal gland and oedema in the heart muscle. Similar lesions have arisen in animals following chronic administration.
In overdosage situations the stomach should be emptied promptly by induced emesis or lavage. There is no specific therapy for acute overdosage with Disulfiram (Antabuse) tablets and general symptomatic and supportive measures should be instituted and maintained for as long as necessary.
Warnings and precautions:
Adverse reactions, side effects:
Most common adverse reactions of disulfiram include heart failure, seizures, optic neuritis, hepatic failure, acute generalized exanthematous pustulosis (AGEP).
To report suspected side effects of Antabuse (Disulfiram) tablets contact pharmaceutical companies manufactured and distributed this medication, or your local FDA.
Use in specific populations:
The safe use of disulfiram in pregnancy has not been established. Therefore, disulfiram should be used during pregnancy only when, in the judgement of the physician, the probable benefits outweigh the possible risks.
According to the manufacturer, it is not known if disulfiram is excreted into human milk, and disulfiram should not be given to mothers who are breast-feeding.
Paediatric and elderly patients
No data available.
How to store:
Keep disulfiram tablets out of the sight and reach of children.
Store below 25°C.
Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
APIs used in medicine in combinations with disulfiram:
Here is a list of popular medications containing disulfiram as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug||Pharmaceutical forms and doses||Companies|
Revised: August 2021